Cancer blood test moves closer after promising results
A British team of researchers has developed what might be a simple blood test that can detect all cancers.
Scientists from the University of Bradford have so far used their technique on three types of cancer with promising results.
It is hoped that in time the test could prevent costly and invasive procedures such as colonoscopies and biopsies.
But researchers say it is still very early days and much more work is needed.
Blood tests have been used before to detect different types
of cancer, but the Bradford team hopes to develop a universal test for
all cancers.
The technique involves subjecting white blood cells to ultraviolet light which damages the cells' DNA.
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Prof Diana Anderson University of Bradford School of Life SciencesWe found that people with cancer have DNA which is more easily damaged by ultraviolet light than other people”
So far tests on the blood of
melanoma, colon and lung cancer patients have shown the DNA is more
easily damaged compared with healthy volunteers.
Those patients with pre-cancerous conditions showed an intermediate level of damage.
The researchers believe the results would not be affected by illnesses such as colds or flu that may affect the immune system.
Their work is published in the FASEB Journal.
'Stressed'
Prof Diana Anderson, from the University of Bradford's School
of Life Sciences, who led the research said: "White blood cells are part
of the body's natural defence system.
"We know that they are under stress when they are fighting
cancer or other diseases, so I wondered whether anything measureable
could be seen if we put them under further stress with UVA light.
"We found that people with cancer have DNA which is more
easily damaged by ultraviolet light than other people, so the test shows
the sensitivity to damage of all the DNA - the genome - in a cell.
"These are early results completed on three different types
of cancer and we accept that more research needs to be done; but these
results so far are remarkable."
That view is backed by Cancer Research UK, which emphasised the research was at a very early stage.
Dr Anthea Martin, Cancer Research UK's science information
manager, said: "Diagnosing cancer earlier is key to improving the
chances of survival, but any new technique must be thoroughly trialled
to make sure it is reliable and accurate.
"Although this small study is interesting, there are still a
lot of unanswered questions about this test and much bigger studies are
needed to prove whether it could be useful for diagnosing cancer on a
wider scale."
However, Professor Shirley Hodgson, a professor of cancer
genetics, at St George's, University of London, was more sceptical about
the University of Bradford study.
"Overall, this is a small study with very significant
limitations," she said. "We cannot derive from this study an indication
that the comet assay test [the technique used in the Bradford study]
can detect cancer, and certainly not all cancers.
"A much bigger experiment, including better-controlled groups
of patients, is needed before we can determine how useful the test
could be in cancer diagnosis."
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